Category Archives: Metabolism
From the Desk of Dr. Hildy
© October 9, 2013
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FOLIC ACID and Generations to Come
Recently an article by Ms. Mae Chan entitled, “Folic Acid Deficiencies May Impact Up to Five Generations Later” was recently published in Cell.com © (October 6, 2013). The entire article is stated below my article. The aspect of the impact of epigenetic risk markers for a deficiency of folic acid is very true, but remember if you eat the proper foods rich in folic acid, reduce body exposure to hazardous materials, heavy metals and other toxicants and keep up a good abundance of glutathione rich foods and natural sources, the body will become over-joyed with its ability to protect and nourish your temple – the HUMAN BODY.
Folic acid has been recognized as one of the B vitamins necessary for good nutrition. Its chemical formula is C19H19N706 and it is slightly soluble in water and easily oxidized in acid and sunlight. It helps in the growth of a healthy blood system and aids the intestinal tract to stay healthy. It has been indicated that up to three milligrams daily would be an adequate amount. The bacteria in the intestines will ordinarily work to combine or synthesize various elements together to form folic acid. When one is exposed to pesticides, heavy metals, mold and their mycotoxins and may other toxic substances this natural process will become interrupted and the loss of natural gut flora will follow. As more natural gut flora is lost the more symptoms of ill health one will have over time, which will lead to chronic disease patterns.
A deficiency of this B vitamin may have serious results for the expectant mother. The condition of a congenital fissure or split in the roof of the mouth, known as cleft palate may be the result of a deficiency in folic acid substances. This is also found in spina bifida and children born with no eyes as found in the early cases of exposure to a pesticide known a benomyl in the late 1980’s and early 1990’s in the USA. The pesticide inhibited AMOG enzyme as a result of reduced folic acid and vitamin B12 levels with acetyl cholinesterase activities. Also, although it is not certain, this deficiency may contribute to other conditions of the newborn child such as horseshoe kidneys (union of the kidneys at the lower ends) a, hydrocephalus (fluid within the cranium), harelip, and heart and brain defects.
Anemia is one of the conditions that may result from a deficiency in folic acid. Individuals taking such drugs as aminopterin, streptomycin and the sulfa drugs or exposed to carbamate pesticides (Example: benomyl or methomyl) must be warned that these drugs destroy folic acid.
The condition known as sprue, where there is a sore mouth, ingestion and diarrhea, may also result from the lack of folic acid. There may also be the result of a shortage of the large red blood corpuscles, the condition known as megaloblastic anemia.
M. Ebbing, et. al., “Cancer incidence and mortality after treatment with folic acid and vitamin B12” (2009) in the Journal of American Medical Association evaluated the effects of treatment with B vitamins on cancer outcomes and all-caused mortality in 2 randomized controlled trials. During the study treatment, median serum folate concentration increased more than 6-fold among participants given folic acid. The results were mainly driven by an increased lung cancer incidence in participants who received folic acid plus vitamin B-12. Vitamin B-6 treatment was not associated with any significant effects. Ebbing, et.al.’s conclusion in this study was that treatment with folic acid (plus vitamin B-12) was associated with an increased cancer outcomes and all-cause mortality in patients with ischemic heart disease where there is no folic acid fortification of foods in Norway.
It is very important to note that the Edding, et.al. study at the Haukeland University Hospital, Bergen, Norawy did not address the interaction of the enzyme B-transferase, which is needed for the metabolism of the B vitamins. Lack of enzyme B-transferase will cause reduction of B vitamin absorption and reduced oxygen levels that may give additional rise to superoxides. And, the study did not identify if the participants in their study did not have the mutated gene of folate/folic acid absorption, which does not allow the vitamin to be metabolized quickly, but slower, thus causing an accumulation within the blood as illustrated in their study. Lack of Vitamin B-6 does cause arteriolsclerosis in humans and other mammals.
It is found abundantly in spinach, watercress and the greens of mustard, beet turnips, parsley, carrots, broccoli and generally in almost all green leaves of vegetables and herbs. It is also found in mushrooms, soybeans and wheat germ. For non-vegetarians it is also found in liver and milk.
1) Kadans, Joseph M. Encyclopedia of Fruits, Vegetables, Nuts and Seeds for Healthful Living. Parker Publishing Company, Inc. West Nyack, New York. © 1973
2) Sacarello, Hildegarde. “Human Toxicological Effects of Benlate.” News Letter World Safety Organization. World Safety Organization, Dolphian, MO (C) 1991
3) Ebbing, M., Bonaa, KH, Nygard, O. Arnesen, E, Ueland, PM, Nordrehaug, JE, Rasmussen, K, Njolstad, I., Refsum, H, Nilsen, DW, Tverdal, A., Meyer, K. and SE Volset. “Cancer incidence and mortality after treatment with folic acid and vitamin B12.” JAMA, 2009 Nov 18; 302 (19): 2119-26. Doi: 10.1001/jama.2009.1622 http://www.ncbi.nlm.nih.gov/pubmed/19920236
What You Should Know About Folic Acid – YouTube
www.cell.com Article published October 6, 2013 by MAE CHAN
Folic Acid Deficiencies May Impact Up To Five Generations Later
Folic acid has been found to boost male fertility, vascular function and even prevent cancer. Writing in Cell, a research team revealed that epigenetic risk markers for disease caused by folic acid deficiency can be passed on up to five generations and could have an impact on developmental risk factors and later risk of disease.
“Although our research focused on genetic mutations which disrupts the break down and metabolism of folic acid, we believe that folic acid deficiency in the diet would have a similar multi-generational impact on health,” explained Dr Erica Watson from the University of Cambridge, who led the study.
The researchers found that when either the maternal grandmother or the maternal grandfather had a specific genetic mutation (known as Mtrr mutation) that caused a folic acid deficiency, their genetically normal grandchildren who did not have the genetic mutation and did not suffer from folic acid deficiency were still at risk of a spectrum of developmental abnormalities.
“It surprised us to find that the great, great grandchildren of a parent who has had a folic acid deficiency could have health problems as a result – suggesting that the ‘sins of your maternal grandparents’ can have an effect on your development and your risk for disease,” said Watson.
“More importantly, our research shows that disease in general can be inherited through epigenetic means rather than genetic means, which has huge implications for human health. Environmental factors that influence epigenetic patterns — e.g., diet, epigenetic disruptors in the environment such as chemicals, etc. – may also have long term, multigenerational effects,” she said.
Folic Acid Fortification
The detrimental effects of folic acid deficiency on development are quite well known, and can include developmental problems such as spina bifida, heart defects and placental abnormalities. However, until now, very little was known about how folic acid deficiency caused the diverse range of health problems in offspring.
As a result, many countries have implemented folate fortification programmes which require folic acid to be added to cereal products.
“Fortification programmes may have reduced the risk of health effects but not eliminated them completely,” said Watson. “Based on our research, we now believe that it may take more than one generation to eliminate the health problems caused by folate deficiency.” Folate is a very important B vitamin, and low levels may be involved in certain carcinogenic processes. If more people could supplement their folate intake from fruits and legumes, rather than from a folic acid supplement it could condition the population to regulate from a natural source as synthetic fortification is far inferior to natural sources of folate. These foods have other cancer-fighting properties and can help protect against other chronic diseases. Inherited Epigenetics
Through another experiment which involved transferring the embryo from the third generation into a normal healthy female mouse, the team discovered that the developmental abnormalities seen in later generation were not passed down genetically.
Instead, the serious defects were the result of epigenetic changes which had been inherited, said the authors.
Epigenetic inheritance refers to the passing of these epigenetic marks from one generation to the next – despite the epigenome, for the most part, being ‘wiped clean’ after each generation, explained Watson.
The team suggested that, for a yet unknown reason, some of these abnormal epigenetic marks caused by the Mtrr mutation, or indeed dietary folic acid deficiency, may escape this normal eradication and are inherited by the next generation.
If these abnormal epigenetic markers that regulate genes important for development are inherited, then subsequent generations may develop abnormalities as a result of the wrong genes being turned on or off, they said.
by Dr. Hildegarde Staninger®, RIET-1
© July 1, 2013
ACETAMINOPHEN & PARACETAMOL and THEIR REACTION TO GLUTATHIONE
Recently, I co-authored a paper that is being published by the National Registry of Environmental ProfessionalsTM, Glenview, IL for their Professional Journal. The paper is entitled: “Glutathione and Its Role in the Biotransformation of Toxicants.” The paper is a must read paper for anyone who has been exposed to industrial solvents, venoms, hazardous materials, medications and other toxic chemical substances. The paper did not address a primary study that was conducted by J.R. Mitchell (1973) which specifically addressed the protective role of glutathione upon induced hepatic necrosis from exposure to the compound acetaminophen (paracetamol, the international nonproprietary name) an active ingredient in the medication Tylenol®.1, 2, 3a,b
The paper discusses the role of Xenobiotics and their metabolites. A xenobiotic is a chemical which is found in an organism but which is not normally produced or expected to be present in it. It can also cover substances which are present in much higher concentrations than are usual. Specifically, drugs such as antibiotics are xenobiotics in humans because the human body does not produce them itself, nor are they part of a normal diet.
Natural compounds can also become xenobiotics if they are taken up by another organism, such as the uptake of natural human hormones by fish found downstream of sewage treatment plant outfalls, or the chemical defenses produced by some organisms as protection against predators.
However, the term xenobiotics is very often used in the context of pollutants such as dioxins and polychlorinated biphenyls and their effect on the biota, because xenobiotics are understood as substances foreign to an entire biological system, i.e. artificial substances, which did not exist in nature before their synthesis by humans. The term xenobiotic is derived from the Greek words ξένος (xenos) = foreigner, stranger and βίος (bios, vios) = life, plus the Greek suffix for adjectives -τικός, -ή, -ό (tic).4 a, b
Free reactive electrophilic intermediates of xenobiotics can produce damage to important cellular consitituents. Reduced gluathione and the glutathione S-transferase protect cells from this damage by capturing reactive electrophiles before they react at nuceleophilic sites critical to cell viability.5
The metabolism of acetaminophen, an analgesic that at high doses can produced hepatic necrosis, serves as an example of this protective system. A large body of work has shown that one of the principal ways in which acetaminophen produces its hepatotoxicity is via the reactive intermediate, N-acetyl-p-benzoquinone imines shown in Figure 1. This intermediate is apparently a soft electrophile that reacts readily with the strong, soft nucleophile glutathione. As long as the amount of glutathione present at the site of activation of acetaminophen is sufficient to bind the reactive intermediate, no toxicity ensues. However, as was demonstrated in a classic study by Mitchell et al.6, when glutathone is depleted by pretreatment with diethylmaleate, the benzoquinone imine covalently binds to tissue proteins resulting in tissue necrosis. Mitchell et. al.6 were among the first to propose that glutathione plays a fundamental role in protecting tissue against electrophilic attack by xenobiotics.7
Since these early studies demonstrating the protective role of glutathione, many compounds have been shown to form conjugates with glutathione. The protective interaction of glutathione and its primary sulfur dependent enzyme, glutathione-S-transferase play a major role in hormonal regulation of substrate supply to the small intestine. Insulin, glycogen, and catecholamines are the most important hormones that regulate the supply of glucose, fatty acids, and ketone bodies in most tissue. Early studies by W.C. Hulsmann concluded that the direct effect of these hormones on small intestinal epithelium may be modest or negligible, while interaction of streptozotocin-diabetic rat, showed the vascularly profused small intestine diminished glucose utilization. This, however, is probably due to the glucose sparing action of fatty acids and ketone bodies upon intestinal energy metabolism, because of the observation that in diabetes the rate of lactate formation is not decreased.8 a,b, 9
It is very important to note that glutathione plays a major role in detoxification, walling up the toxicants and adding a chain of beneficial mechanisms need to protect one from the chronic effects of hormones, such as thyroid hormones and glucocorticoids that are further stimulated or inhibited upon exposure to thiols/mercaptans.10
1) Staninger, Hildegarde and Daniel F. Farrier. Glutathione and Its Role in the Biotransformation of Toxicants. Journal of the National Registry of Environmental Professionals. Glenview, IL © June 28, 2013.
2) Sacarello, Hildegarde and Scott J. Evans. Genetic Cancer Risk Assessment of Electrophilic Hydrocarbon Mixtures in Subsurface Water Supplies. US EPA Agency: Research and Development. Symposium on short-Term Genetic Bioassays in the Evaluation of Complex Environmental Mixtures. Hotel Europa. Chapel Hill, North Carolina. March 27-29, 1984
3) (a) Hayes, A. Wallace. Principles and Methods of Toxicology, Second Edition. Chapter 2: Metabolism: A Determinant of Toxicity by J. Donald deBethizy and Johnnie R. Hayes. Raven Press, Ltd., New York, New York © 1989 pgs 29-69.
(b) Mentuccia, Roberto and Hildegarde Staninger. Increase or Boost Your Metabolism. Integrative Health Systems®, LLC. Los Angeles, CA © June 7, 2011
5) Mitchell, J.R. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J. Pharmacol. Exp. Ther., 187: 211-217, © 1973
6) Mohandas, J., Duggin, G.G., Horvath, J.S. and D.J. Tiller. Metabolic oxidation of acetaminophen (paracetamol) mediated by cytochorme P-450 mixed-function oxidase and prostaglandin endoperoxide synthetase in rabbit kidney. Toxicol. Appl. Pharmacol. 61:252-259.
7) Morgan, E.T., and M.J. Coon. Effects of cytochrome b5 on cytochrome P-450 catalyzed reactions: Studies withmanganese substituted cytochrome b5. Drug Metab. Dispos., 12: 358-364.
8) (a) Hulsmann, W.C. Abnormal stress reactions after feeding diets rich in (very) long chain fatty acids: high levels of corticosterone and testosterone. Mol. Cell. Endocrinol., 12: 1-8 (C) 1978
(b) Hulsmann, W.C. Energy metabolism in different preparations of rat small intestinal epithelium. In: Intestinal Permeation. Proceedings of the Fourth Workshop Conference Hoescht, edited by M. Kramer and F. Lauterbach, pp. 229-239. Excerpta Medica Intern. Congress Series 391, Excerpta Medica, Amsterdam.
9. Lamers, J.M.J. and W.C. Hulsmann. The effects of fructose on the stores of energy-rich phosphate in rat jejunum in vivo. Biochim. Biophys. Acta. 313: 1-8. © 1973
10. Schille, Carol M. Intestinal Toxicology. Target Organ Toxicology Series. Editor-in-Chief Robert L. Dixon. Raven Press, Ltd. New York, New York © 1984
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‘Folie à deux and other tales of Morgellons and Nano’ is a no-budget documentary film derived from a series of interviews conducted between 2008-2010, on the subject of Morgellons Disease. This film will be making history by offering images and information that has never been available to the general public, until now. First time producer/director Veronica Hendricks offers the world the opportunity to open a new, desperately needed dialog on a subject that is as complex as it is controversial. ‘Folie à deux and other tales of Morgellons and Nano’, focuses on the human aspect of this important issue and gives sufferers of Morgellons disease an explanation to a problem most doctors believe exists only in the mind. Written by Anonymous
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I’ve been researching Morgellons since spring of 2008, when I witnessed the most frightening thing I’ve ever seen, a nano wire moving in and out of my friend’s chest.
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4/3/12 – FromTheDeskOfDrHildy: Series 3 – Poison’s My Game! What’s Yours? Nano Crystals and Modified Food Starches
© April 2, 2012
Series 3: Poison’s My Game! What’s Yours?
Nano Crystals and Modified Food Starches
I have been asked by several of my associates to condense this particular blog into terms that the average reader may relate to in their home, work environment or within their everyday life style. Well, if anyone knows me, sometimes it is hard to candy coat a technical piece, make it easier to understand or try to explain something technical to a non-technical minded person – so here goes.
Modified food starch is a term used in industry for any food starch that has something added to it or changed from its original form. Food starches come from potatoes, corn and other similar produce that has a high starch yield in its chemical composition. You may use corn starch to thicken your gravies, make fruit pie filling Read the rest of this entry →
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From the Desk of Dr. Hildy™
© March 21, 2012
Series 1: Vitamins & Minerals
Vitamin B2, also known as Vitamin G, was
discovered in 1932 and given its name and identity in 1937. It’s chemical formula is C17H20N4O6. It is also known as riboflavin.
It is an important factor in growth and development of the body and promotes a healthy condition of the skin. It is especially valuable in combination with Vitamin A for prevention and correction of cataracts and for health of the skin, hair and eyes. This vitamin is also important to the body in assimilating iron and proteins. Being water-soluble, it is not easily stored in the body. It is affected by light but not by air or heat. An important chemical function of this vitamin is to break down starches and sugars into
energy, a function similar to that of Vitamin B1. This enables the body to better resist infectious disease and is necessary for good health and vitality. An ample supply of this vitamin will help produce healthier offspring and delay the bodily changes that often accompany increasing years of life. It is said that the Centenarians of Bulgaria have a diet rich in Vitamin B2.A lack of Vitamin B2 may cause inflammation of the membrane of the eye and eyelids (conjunctivitis), lips that become sore and red and later cracked and peeled, especially at the mouth corners. Often, the first sign of deficiency is dimness of vision at a distance or in poor light. The cornea (the white, glasslike area of the eyeball) may become bloodshot and inflamed if the deficiency is allowed to continue. The theory is that this vitamin carries oxygen, and when no oxygen arrives the body forms new blood vessels to bring oxygen to the parts lacking it. An absence of riboflavin produced cataracts in experimentations.
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March 6, 2012 VITAMINS and MINERALS
I want to thank all of the readers of this blog/column for joining us here, for you will gain tidbits of information to help yourselves in your everyday life and reduce your exposure to toxic substances from our environment and other areas where exposures occur. Over the last 4 decades of gaining knowledge about vitamins and minerals, I have learned the important roles they serve in our physiology and cellular metabolic applications. Since the introduction of hazardous materials, toxic substances, exposures to mold, advanced nano materials and many other parameters that synergistically effect life’s cellular activities, all life has been affected to a maximum degree by their toxicological effects. These effects are many times subtle, due to the human body always trying to make up for something going on within its basic cell structure, tissues and organ systems.
I will be writing this blog/column to bring to my readers information I feel is important to know, learn and to utilize in your everyday life, because everyone must take care of themselves, then they can take care of others – especially their family members.
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Roberto Mentuccia & Dr. Hildegarde Staninger™, RIET-1
Integrative Health Systems™, LLC © June 7, 2011
What is the Definition of Metabolism?
Metabolism is a term used to describe the process of breaking down a complex molecule to produce energy. Think of your body’s metabolism as a furnace, (it will help for explanation purposes). Often metabolism is associated with the term BMR which stands for Basal Metabolic Rate (also called Resting Metabolic Rate or RMR). BMR is a term used to describe the amount of energy your body uses at rest to survive. Increasing your Basal Metabolic Rate is a highly desirable effect which most of society is trying to achieve. You can purchase a BMR calculator or search the internet for an automatic calculator to assist you.