Dec. 2013 – HOLIDAY SPECIALS! Dr. Hildy Recommends…

         How antioxidants work – Lester Packer, Ph.D., et al 

“For one thing, cancer is not one disease, but an umbrella term for many different diseases, all characterized by the abnormal growth of cells.”  ~ Lester Packer, Ph.D. and Carol Colman authors of The Antioxidant Miracle © 1999.

To ORDER Any of Dr. Hildy’s Fine Products Contact:

Integrative Health Systems®, LLC
ihs-clients@sbcglobal.net
415 ¾ N. Larchmont Blvd.
Los Angeles, CA  90004
Phone:  323-466-2599
Fax:      323-466-2774                                         

Merry

 

To Send CC Information by Fax:
Download and CLICK and print the
and FAX:  323-466-2774
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To Send a Check or Money Order
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Mail with check to:
Integrative Health Systems, LLC
415-3/4 North Larchmont Blvd.
Los Angeles, CA 90004

 

DECEMBER 2013 – Specials
 Dr Hildy ® RECOMMENDS……

(If you order 5 or more products you will receive a Complimentary Copy of Dr. Hildy’s book:  Portals to Destiny)

~ BACK IN STOCK For the Holidays ~

Baci Man – with Jerusalem Artichoke Powder
60 capsules
$39.95 + Shipping – while supplies last
        *Aids in removing toxins, weight loss and metabolism*
2 capsules Morning and Evening
Ingredients: Jerusalem Artichoke Powder, Okra, Nasturtium, Mango and Hungarian Paprika

~~ HOLIDAY SPECIALS ~~

Alpha Lipoic Acid, 1,000 mg – 60 Capsules – $19.95 + Shipping
 
(alpha) Lipoic Acid
  • Lipoic acid is the only antioxidant that can significantly boost the levels of glutathione by approximately 30%.
  • Can regenerate water-soluble vitamins (C and glutathione) and fat soluble (vitamin E) antioxidants
  • Aids in restoring the oxygen molecules to create free radical bursts, which overwhelm the brain’s antioxidant defenses.
  • Aids in brain and heart repair after a stroke from oxygen deficiencies within a cell.
  • Works with l-carnitine, to rejuvenate mitochondria as it restores energy.
  • Aids in detoxification of cellular membrane and cytoplasmic toxins as it, also suppresses and blocks bad genes from expressing themselves from toxic exposures.
  • A molecular cousin to the B vitamin Biotin.  If taking over 100 mg  lipoic acid, add some Biotin to the diet.
===========
Curcumin (active ingredient in Tumeric) 1,000 mg –
60 Capsules – $19.95

 A “spice of life’ used to promote good digestion, fight infection, treat liver problems and relive arthritis.

  • Curcuminoids work well in relieving pain and stiffness from arthritis
  • Lower blood pressure and reduce inflammation.
  • Inhibits the formation of many different types of cancer in animals exposed to known carcinogens.
  • Curcuminoids help to modulate the effects of nitric acid that is produced by immune cells and can be harmful to the cell if not removed.
600 Reasons Turmeric May Be The World’s Most Important Herb
.
Turmeric: A Wellness Promoting Tonic At Low Doses, Research Reveals
http://wakeup-world.com/2013/12/11/turmeric-a-wellness-promoting-tonic-at-low-doses-research-reveals/
.
The Most Exhaustive Turmeric Research Archive on the Internet: GreenMedInfo.com – YouTube
http://www.youtube.com/watch?v=s2AZOMu0bVA
===========
SOD Cream (Super Oxide Dismutase) – 4 oz. squirt bottle –    Special  $19.95 + Shipping
* For the face, neck and hands, and absorption into the body
* A powerful antioxidant that helps to reduce free radical oxidative damage (for example, to reduce fibrosis following radiaton for breast cancer)and promotes cell reproduction if the skin tissue.  Supports the natural skin oxidation process.
  • A powerful anti-inflammatory compound for colitis.
  • Aids in decreasing reactive oxygen species generation and oxidative stress
  • Inhibits endothelial activation and indicates that modulation of factors that govern adhesion molecule expression and leukocyte-endothelial interactions.
  • Aids as a therapy for  inflammatory bowel  disease.
  • Aids in reducing free radical damage to the skin and is known to reverse fibrosis, perhaps through reversion of myofibroblasts back to bibroblasts.
  • SOD is not expressed in neural crest cells in the developing fetus.  Hence, high levels of free radicals can cause damage to them and induce dystrophic anomalies (neural tube defects).
  • Aids in reducing the effects of hypertension, Chronic obstructive pulmonary disease (COPD) and Acute Respiratory Distress Syndrome (ARDS).
  • SOD is known as the most “ancient” metalloenzymes and has been found within both prokaryotes and eukaryotes.
  • SOD protects from the superoxide radical (O2), which is known to denature enzymes, oxidize lipids and fragment DNA.  SOD catalyzes the production of O2 and H2O2 from the superoxide radical, too.
  • Note :  Mutations in SOD-1 have been linked to cause familial amyotrophic lateral sclerosis (ALS), a form of motor neuron disease.  The most common mutation in the U.S. is A4V, while the most intensely studies is G93A.  Several prokaryotic SOD null mutants have been generated, including E. coli.  The loss of periplasmic  CuZnSOD (SOD-1) causes loss of virulence and might be an attractive target for new antibiotics.
http://onecellonelightradio.files.wordpress.com/2013/12/superoxide_dismutases.pdf 
Dr. Hildegarde Staninger™, RIET-1, Integrative Health Systems™, LLC, ©September 2009 –  PowerPoint-Superoxide-Dismutase-SOD, Staninger, September, 2009
=========
Retinol A Cream – 4 oz squirt bottle – Special $19.95 + Shipping
  • Active components of vitamin A, a powerful protection factor against various types of cancer.
  • Boosts the immune system as it aids in cellular regeneration inside and outside.
  • Anti-wrinkle and aid in free radical suppression.
  • Aids in color protection of rods within the eye for black and white vision.
  • Protects skin against cancer and promotes healthy skin.
  • Reduces tumor formation by 76% per Cleveland Clinic.

 Beta Glucan Cream – 4 oz squirt bottle – Special $19.95 + Shipping 

  • The natural cellulose component of plants (yeast, barley (aids with diabetes), fungi, mushrooms, bran, oats, rye and wheat.
  • Aids in reduction of tumoricidal effects.
  • Aids in the prevention of infection.
  • Aids with allergic rhinitis.
  • Aids in reducing arthritis pain.
  • Contributes to maintenance of normal blood cholesterol  concentrations.
  • Aids in reducing disease risk as recognized by the European Food Safety Authority (EFSA).
  • Yeast and medicinal mushrooms derived beta glucan are noted for their ability to modulate the immune system.

Co Enzyme Q10 – 4 oz Squirt Bottle – Special $19.95 + Shipping

  • Boosts the effectiveness of T ccells.
  • Aids in recycling vitamin E.
  • Rejuvenates the brain and nerve cells as seen in amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig’s disease.
  • Reduces oxidative stress.
  • Helps promote healthy gene expression.
  • Reduces plaque and gum disease.
  • Supports collagen in gum tissue and skin as it aids in energy production.

Progesterone – 4 oz squirt bottle – Special $19.95 + Shipping

  • Lack of progesterone can cause irregular female menstrual cycle.
  • It is needed in embryogenesis of humans and other species.
  • Progesterone is produced in the ovaries (by the corpus luteum), the adrenal glands (near the kidney) and during pregnancy, in the placenta.   Progesterone is also stored in adipose (fat) tissue.
  • Yam and sweet potatoes contain high amounts of saponins- which are convertible to progesterone.
  • When lacking progesterone elevated levels of cholesterol may form, due to the body’s need to oxidize cholesterol into progesterone.
  • Males and females are affected by low levels of progesterone by reduction in adrenal cortical steroids.
  • Elevated  levels of progesterone is associated with temporary increase in sodium retention (reduced natriuresis, with an increase in extracellular fluid volume) due to the compensatory increase in aldosterone production, which combats the blockade of the mineralocorticoid receptor by the previously elevated level of projecterone.
  • Progesterone modulates activity of CatSper (cation channels of sperm) voltage-gated Ca2+ channels.  Since eggs release progesterone, sperm may use progesterone as a homing signal to swim toward eggs (chemo taxis).  Hence substances that block the progesterone binding site on CatSper channels could potentially be used in male contraception.

To ORDER Any of Dr. Hildy’s  Fine Products Contact:

Integrative Health Systems®, LLC
ihs-clients@sbcglobal.net
415 ¾ N. Larchmont Blvd.
Los Angeles, CA  90004                                                     

Phone:  323-466-2599
Fax:      323-466-2774

Visit  FROM THE DESK OF DR. HILDY and Dr. Hildy’s OneCellOneLight Radio Show Website for ‘Integrative’ Information
http://www.onecellonelightradio.wordpress.com 

A Warm Kitty MERRY CHRISTMAS from all of us – Dr. Hildy, Roberto, Shoshanna, Eric and Richard

kitty

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From the Desk of Dr. Hildy – **WONDERFUL Prosperity THOUGHT FOR THE DAY**

blessings

*^*^*^*^*^*^*^*^*^*^*^*

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You cannot notice what-is and complain about it, and be a vibrational match to the solution. When you were living the problem, you were asking for the solution, and Source said yes immediately.

So, there’s never a reason for you to be wallowing around in a problem for more than about a second? You can get so good at this that before you’re even aware that the problem has gotten started, you’ve already got the solution under way.

—Abraham

7-10-13 – Dr. Hildy- GLUTATHIONE and ITs Role in the BIOTRANSFORMATION of TOXICANTS

JOIN US FRIDAY 9/13/13 FOR A SPECIAL ON PROSTATE AND BREAST
CANCER and MORE+++ in the meanwhile, ENJOY THIS ***ENCORE***

One Cell One Light®Radio

7-10-13 – Dr. Hildy- GLUTATHIONE and ITs Role in the  BIOTRANSFORMATION of TOXICANTS

OneCellOneLight® Radio | Blog Talk Radio
Wednesday, July 10, 2013, 1:00-3:00PM Pacific
(2-4pm Mountain; 3-5pm Central, 4-6pm Eastern)

Listen to Hour 1 and Hour 2 in separate .mp3 audios:

Hour 1 Audio:  Hour 2 Audio:

CLICK Here to Listen to the full 2-hour show:
http://www.blogtalkradio.com/onecellonelightradio/2013/07/10/7-10-13–dr-hildy-glutathione-and-its-role-in

~~~~~~~~~~~~~~~~~~

This week on One Cell One Light Radio, Dr. Hildy and Producer Sho Allison
host a very special discussion on a very special molecule:
Glutathione

###
Glutathione and IT’s Role in the Biotransformation of Toxicants – .PDF
by Dr. Hildegarde Staninger®, RIET-11and Daniel F. Farrier, MD2
© June 28, 2013 (Submitted for publication to the Journal/Magazine of the National Registry of Environmental ProfessionalsTM, Glenview, Illinois on June 30, 2013)
###

Which is what, exactly?  Glutathione is an antioxidant that acts as a regulator for many…

View original post 1,074 more words

From The Desk of Dr. Hildy – ‘Solomon’s Seal’ – Aug. 22-24 and 25th – YOU SHALL BECOME PURE PILLARS OF LIGHT

  ~ Solomon's Seal ~

~ Solomon’s Seal ~

The Grand Sextile – August 22nd to 25th – The Solomon ’s Seal –
~Theme~ TRANSFORMATION – Pleiades

THANK YOU to – posted on August 19, 2013

In the next few days of your earthly time, there will once again occur a grand celestial event in your skies as major celestial bodies move into place to form a six pointed star. Another portal will once again open and bring with it a strong infusion of light onto this planet. This is the time that all of you will be able to fully, consciously and collectively connect yet again to the divine. Coupled with the energies that all of you have collected and have hibernated within your vessels for the last few weeks, the energy that will be unleashed onto GAIA will have tremendous power to break down the old systems and to transform all that stands in its way.

And so we ask that all of you, with all of you might and desire for change, connect to the divine and allow your bodies to become light anchors, pillars of light, through which the pure cosmic energies of love, peace, serenity, tranquility and understanding can pass through and into the very depths of your planet.

We ask that as this energy passes through you, for you to completely merge with the energies and to monitor your thoughts continuously for 3 days. One day prior to the portal, during the portal and the next day after the closing of the gates.

You shall become PURE channels of this energy, for all the darkness shall be transformed to light, doubts and fears into confidence and peace. Bear in mind that as this energy passes through you, and cleanses your very being, you may experience various energy fluctuations throughout the 3 day cycle. Please understand that this shall be a natural state, for your bodies will be transformed FOR THE DURATION OF 3 DAYS (22-24)  – YOU SHALL BECOME PURE PILLARS OF LIGHT. Your senses will heighten. Your vision will sharpen. Your hearing will significantly improve. Each word you utter will carry tremendous power within. Your thoughts will quickly manifest into your reality and so we ask all of you to be increasingly aware of these processes and to carefully monitor each and every thought, word and action, for you must think love, breathe love, BE LOVE. You must completely transform yourselves into pure VIOLET FLAME.

Allow the energies to permeate through your body and if you begin to feel anything but love, peace, tranquility and joy, simply shift your focus back to love and light. Remember to keep your thoughts positive, do not allow any negativity to seep through. Simply shift your focus and know that for these 3 days you are an immensely powerful being, carrying pure, crystalline consciousness of the universal truth within your vessel and delivering it to mother GAIA.

And so on the 25th of your August you are to sit in a meditative state and imagine and see and feel and sense yourself to be a pure, pillar of violet flame. See yourself connecting with your crown chakra to the Source. Be sure to “imagine” that your link to The Source is completely protected in golden light as it travels down from The Source into your Crown chakra, going all the way down the center of your body and exiting your body through your base chakra and going all the way down to the very core of the earth. Sit still and breathe deeply in and out. With every breath that you take pull more and more violet flame through your crown chakra, down your body and out of your base chakra into the heart of the earth, from where it shall envelope the whole planet and be distributed to each and every soul that dwells therein. All the while feeling LOVE, COMPASSION, UNDERSTANDING, PURITY, TRUTH, JOY, CONFIDENCE, AND ETERNAL BLISS.

We love you. We are with you. Goodbye for now.

Pleiades High Council – Channeled by Anna Merkaba – Energy Healer- Channeler – Lightworker. –http://sacredascensionmerkaba.wordpress.com/

With best wishes from Dr. Hildy
Dr. Hildegarde Staninger,RIET-1 Industrial Toxicologist/IH & Doctor of Integrative Medicine Integrative Health Systems,LLC
415 3/4 N. Larchmont Blvd
Los Angeles, CA 90004
Phone: 323-466-2599 Fax: 323-466-2774
www.integrativehs.com – product pages                   

From The Desk Of Dr. Hildy – DR. HILDY’S GARDEN COLLECTION

Dr. Hildy®’s Garden

Collection

A Time for Tea,

Your Favorite Recipe

or Bath

ESSENCE

 
Dr. Hildegarde Staninger®,RIET-1, Industrial Toxicologisthas been searching the various lands and seas to bring forth to our clients and patients the most purist and highest bio-active botanicals, that could be found in the world. The Dr. Hildy®’s Garden Collection is a collection of Authentic Natural Pure Spice Essencethat allows you to add taste to a hot cup of tea or beverage and use it in your favorite cooking recipes.  You may even squirt it in your bath or foot bath water to give you the added botanical health benefits to your skin and body. The precious anti-oxidants, rich flavors and natural phytochemicals, all remain intact and ready for instant release as you simply pump into water, juices or any liquid base. There is absolutely no waste and each bottle does 100 servings of instant flavor, no heating required, disperses evenly, long shelf life for a Natural and Healthy product.

The Introductory Offer to the Dr. Hildy®’s Introductory Garden Collection was hand-picked by Dr. Staninger to include her favorite spices, which would help nurture your bodies healing process, as it became more naturally radiant.

She recommends that you may use

1 squirt in your favorite beverage or foot bath water

and 2 squirts for your bath tub water. 

These spices may be used individually in the bath or with:   

Baci Mi® Bebe Bath Time

 Chac Mool®  Yellow/Clear/Jade/Purple

or Willard’s Water® for added benefits.***

Pure Spice Essence was created by Primal Essence, Inc, Oxnard, CA. It is made of high grade, non-irradiated spices and uses ultra high technology called Supercritical Fluid Extraction. The yield is a pure, chemical-free, alcohol-free, Pure Spice Essence, which is many times more potent than any dried herb or spice product.

The ‘Pure Spice Essences’ Health Benefits and Healing Properties are as follows for each of the DR. Hildy®’s selected spice/herbs ~

 Lemongrass, Basil and Peppermint

for this special

Introductory Garden Collection bundle.

 Lemon Grass~Lemongrass~ has been recommended for cough, cold & sore throat; anxiety, high cholesterol, Type 2 diabetes; colitis, digestion; rough, dry, scaly skin; acne; constipation; kidney detoxification; insomnia; relaxation and deep sleep. Lemongrass contains citral which has strong anti-microbial and anti-fungal properties.  Its leaves and stems are high in folic acid and essential vitamins such as pantothenic acid (vitamin B5), pyridoxine (vitamin B6) and thiamin (vitamin B1). It also contains many anti-oxidant minerals and vitamins such as vitamin C, vitamin A, potassium, zinc, calcium, iron, manganese, copper and magnesium.  Lemongrass is highly effective in flushing toxins and wastes out of the body; improving the function of many different organs including the liver, spleen and kidneys.

PEPPERMINT~Peppermint ~ has been recommended for acne, headaches, migraines, head lice, irritable bowel syndrome, menstrual cramps, pain relief, sinusitis, colds, stress and anxiety. Studies have shown that Peppermint can help with a number of health conditions. It is known to have analgesic, anesthetic, decongestant, astringent, antiseptic, antibacterial, antimicrobial, antispasmodic, and carminative properties. Therefore, it has been found beneficial in the treatment of many conditions including colds, flu, sinusitis, dry cough, fever with chills, nausea, digestive problems, mood swings and emotional imbalance.

~BBASILasil ~ Basil is known as the “Mediterranean”cultivar typically called sweet basil. Its leaves contain many notable plant derived chemical compounds that are known to have disease preventing and health promoting properties, anti-oxidant protection against radiation-induced lipid peroxidation from its polyphenolic flavonoids like orientin and vicenin, while eugenol, citronellol, linalottl, citral, limonene and terpineol are known to have anti-inflammatory and anti-bacterial properties.   It is low in calories and contains no cholesterol, but is very rich source of many essential nutrients, minerals and vitamins that are required for optimum health. 

Basil herb contains exceptionally high levels of beta-carotene, vitamin A, cryptoxanthin, leutein and zeaxanthin. These compounds help act as protective scavengers against oxygen-derived free radicals and reactive oxygen species (ROS) that play a role in aging and various disease processes.  Zea-zanthin, a yellow flavonoid carotenoid compound, is selectively absorbed into the retinal macula lutea where it is found to filter harmful UV rays from reaching the retina. Studies suggest that common herbs, fruits, and vegetables that are rich in zea-xanthin anti-oxidant help to protect fro age-related macular disease (AMRD), especially in the elderly. Vitamin K in basil is essential for many coagulant factors in the blood and plays a vital role in the bone strengthening function by helping mineralization process in the bones.

 

The Suggested Retail Price for each individual squirt bottle of

Pure Essence Spice of

Lemongrass, Peppermint or Basil:

$19.95, each.

ESSENCE

Dr. Hildy®’s Introductory Garden Collection

of ALL 3 Pure Essence Spices:

only $49.95, while supplies last.

Dr. Hildy®’s Introductory Garden Collection is a significant cost savings for YOU, as you get ready to make those special Heirloom Family recipes and just treat yourself to something special.

Just because you are YOU!

ihs-clients@sbcglobal.net  ~   www.onecellonelightradio.wordpress.com

IHS_PRODUCT_GUIDE_DR_HILDY_07-18-2013.pdf

TO ORDER DR. HILDY’s FiNE PRODUCTs:

Integrative Health Systems, LLC
415 ¾ N. Larchmont Blvd.
Los Angeles, CA 90004

Phone: 323-466-2599
Fax: 323-466-2774

eMail: ihs-clients@sbcglobal.net

~~~~~~~~ All information contained herein is for educational purposes. The information has not been evaluated by the Food and Drug Administration, except where FDA documents are provided. The information is not intended to replace medical care, diagnose, treat, prevent, mitigate or cure disease. We believe in the individual’s informed right to choose their own health care methods. As always, consult with a health professional before attempting any self-health program. Your physician can assist you in making  decisions. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

From The Desk of Dr. Hildy – Heirloom Special with ‘A Pinch Of Love…” by Mariana Zaharoff

specialbundle

MARIANA

Our Heirloom Special consists of

“A Pinch of Love in Everything You Cook”

by Mariana Zaharoff,

International Fashion Designer

It takes four hours to Hand PAINT the cook book by Mariana Zaharoff. 

The book is not just a book, it is an Heirloom, that may be passed down through generations or to your favorite person who loves to cook within your family or circle of friends. The Heirloom Bundle is an ideal Birthday, Anniversary, Holiday or just something to give to that special someone in your life – YOU.

The Heirloom Special Bundle contains the following:

                                                            Suggested Retail Price

1-copy of the Cook book by Mariana Zharoff   $  50.00

1- Peppermint liquid spice, 1 oz. Primal Essence, Inc.                                                                                                                         $  19.95

1-Baci Mi® Lemon Drop Gel                                  $  29.95  

                                                                  Total  $  99.90

             ● IHS Special Bundle Price 5% off – $94.50 

                    

The Heirloom Special is Exclusively Offered ONLY at:

Integrative Health Systems®, LLC ~

415 ¾  N. Larchmont Blvd, Los Angeles, CA 90004

(323) 466-2599

ihs-clients@sbcglobal.net

~~!~!~!~!~!~!~!~!~!~!~~

COME LISTEN !! OneCellOneLightRadio

July 17, 2013 – 1:00-3:00PM Pacific
Dr. Hildy is joined by Mariana Zaharoff
and her Grandson, Warren Bisch

www.onecellonelightradio.wordpress.com

FROM THE DESK OF DR. HILDY® – Acetaminophen and Paracetamol – Glutathione Reaction

COME visit the website and listen to the July 10, 2013
OneCellOneLightRadio show with Dr. Hildy® – 1-3:00PM Pacific
 and archived thereafter – 
TODAY’S SUBJECT:
*GLUTATHIONE and It’s Role In The Biotransformation of TOXICANTS*
.
Life and Health Enhancing information!
.
FROM THE DESK OF DR. HILDY®
by Dr. Hildegarde Staninger®, RIET-1
© July 1, 2013

ACETAMINOPHEN & PARACETAMOL and THEIR REACTION TO GLUTATHIONE

Recently, I co-authored a paper that is being published by the National Registry of Environmental ProfessionalsTM, Glenview, IL for their Professional Journal.   The paper is entitled:  “Glutathione and Its Role in the Biotransformation of Toxicants.”  The paper is a must read paper for anyone who has been exposed to industrial solvents, venoms, hazardous materials, medications and other toxic chemical substances.    The paper did not address a primary study that was conducted by J.R. Mitchell (1973) which specifically addressed the protective role of glutathione upon induced hepatic necrosis from exposure to the compound acetaminophen (paracetamol, the international nonproprietary name) an active ingredient in the medication Tylenol®.1, 2, 3a,b

The paper discusses the role of Xenobiotics and their metabolites.   A xenobiotic is a chemical which is found in an organism but which is not normally produced or expected to be present in it. It can also cover substances which are present in much higher concentrations than are usual. Specifically, drugs such as antibiotics are xenobiotics in humans because the human body does not produce them itself, nor are they part of a normal diet.

Natural compounds can also become xenobiotics if they are taken up by another organism, such as the uptake of natural human hormones by fish found downstream of sewage treatment plant outfalls, or the chemical defenses produced by some organisms as protection against predators.

However, the term xenobiotics is very often used in the context of pollutants such as dioxins and polychlorinated biphenyls and their effect on the biota, because xenobiotics are understood as substances foreign to an entire biological system, i.e. artificial substances, which did not exist in nature before their synthesis by humans. The term xenobiotic is derived from the Greek words ξένος (xenos) = foreigner, stranger and βίος (bios, vios) = life, plus the Greek suffix for adjectives -τικός, -ή, -ό (tic).4 a, b

Free reactive electrophilic intermediates of xenobiotics can produce damage to important cellular consitituents.  Reduced gluathione and the glutathione S-transferase protect cells from this damage by capturing reactive electrophiles before they react at nuceleophilic sites critical to cell viability.5

The metabolism of acetaminophen, an analgesic that at high doses can produced hepatic necrosis, serves as an example of this protective system.  A large body of work has shown that one of the principal ways in which acetaminophen produces its hepatotoxicity is via the reactive intermediate, N-acetyl-p-benzoquinone imines shown in Figure 1.  This intermediate is apparently a soft electrophile that reacts readily with the strong, soft nucleophile glutathione.  As long as the amount of glutathione present at the site of activation of acetaminophen is sufficient to bind the reactive intermediate, no toxicity ensues.  However, as was demonstrated in a classic study by Mitchell et al.6, when glutathone is depleted by pretreatment with diethylmaleate, the benzoquinone imine covalently binds to tissue proteins resulting in tissue necrosis.  Mitchell et. al.6 were among the first to propose that glutathione plays a fundamental role in protecting tissue against electrophilic attack by xenobiotics.7

Since these early studies demonstrating the protective role of glutathione, many compounds have been shown to form conjugates with glutathione.  The protective interaction of glutathione and its primary sulfur dependent enzyme, glutathione-S-transferase play a major role in hormonal regulation of substrate supply to the small intestine.  Insulin, glycogen, and catecholamines are the most important hormones that regulate the supply of glucose, fatty acids, and ketone bodies in most tissue.  Early studies by W.C. Hulsmann concluded that the direct effect of these hormones on small intestinal epithelium may be modest or negligible, while interaction of streptozotocin-diabetic rat, showed the vascularly profused small intestine diminished glucose utilization.  This, however, is probably due to the glucose sparing action of fatty acids and ketone bodies upon intestinal energy metabolism, because of the observation that in diabetes the rate of lactate formation is not decreased.8 a,b, 9

It is very important to note that glutathione plays a major role in detoxification, walling up the toxicants and adding a chain of beneficial mechanisms need to protect one from the chronic effects of hormones, such as thyroid hormones and glucocorticoids that are further stimulated or inhibited upon exposure to thiols/mercaptans.10

REFERENCES

1)  Staninger, Hildegarde and Daniel F. Farrier.  Glutathione and Its Role in the Biotransformation of Toxicants.  Journal of the National Registry of Environmental Professionals.  Glenview, IL  © June 28, 2013.

2)  Sacarello, Hildegarde and Scott J. Evans.  Genetic Cancer Risk Assessment of Electrophilic Hydrocarbon Mixtures in Subsurface Water Supplies. US EPA Agency:  Research and Development.  Symposium on short-Term Genetic Bioassays in the Evaluation of Complex Environmental Mixtures.  Hotel Europa.  Chapel Hill, North Carolina.  March 27-29, 1984

3) (a) Hayes, A. Wallace.  Principles and Methods of Toxicology, Second Edition. Chapter 2:  Metabolism: A Determinant of Toxicity by J. Donald deBethizy and Johnnie R. Hayes.  Raven Press, Ltd., New York, New York © 1989 pgs 29-69.

(b) http://en.wikipedia.org/wiki/Tylenol

4)  (a) http://en.wikipedia.org/wiki/Xenobiotic.com

(b) Mentuccia, Roberto and Hildegarde Staninger.  Increase or Boost Your Metabolism.   Integrative Health Systems®, LLC.  Los Angeles, CA  © June 7, 2011

5)  Mitchell, J.R. Acetaminophen-induced hepatic necrosis.  IV. Protective role of glutathione.  J. Pharmacol. Exp. Ther., 187: 211-217, © 1973

6)  Mohandas, J., Duggin, G.G., Horvath, J.S. and D.J. Tiller.  Metabolic oxidation of acetaminophen (paracetamol) mediated by cytochorme P-450 mixed-function oxidase and prostaglandin endoperoxide synthetase in rabbit kidney.  Toxicol. Appl. Pharmacol.  61:252-259.

7)  Morgan, E.T., and M.J. Coon.  Effects of cytochrome b5 on cytochrome P-450 catalyzed reactions:  Studies withmanganese substituted cytochrome b5. Drug Metab. Dispos., 12: 358-364.

8) (a) Hulsmann, W.C.  Abnormal stress reactions after feeding diets rich in (very) long chain fatty acids:  high levels of corticosterone and testosterone.  Mol. Cell. Endocrinol., 12: 1-8 (C) 1978

(b)  Hulsmann, W.C.  Energy metabolism in different preparations of rat small intestinal epithelium.  In:  Intestinal Permeation.  Proceedings of the Fourth Workshop Conference Hoescht, edited by M. Kramer and F. Lauterbach, pp. 229-239.  Excerpta Medica Intern. Congress Series 391, Excerpta Medica, Amsterdam.

9.  Lamers, J.M.J. and W.C. Hulsmann. The effects of fructose on the stores of energy-rich phosphate in rat jejunum in vivo.   Biochim.  Biophys. Acta.  313: 1-8. © 1973

10.  Schille, Carol M.  Intestinal Toxicology.  Target Organ Toxicology Series.  Editor-in-Chief Robert L. Dixon.  Raven Press, Ltd.  New York, New York © 1984

=========Dr. Hildy®‘s Websites =========

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FROM THE DESK OF DR.HILDY® – TIBETAN RAPID EYE MOVEMENT

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FROM THE DESK of DR. HILDY®      Tibetan Rapid Eye Movement
by Dr. Hildegarde Staninger®, RIET-1
Copyright May 2, 2013

TIBETAN REM CHART

                       

*Eye Chart Symbol by Tibetan Lama Monks (6)

Archeological evidence indicates that people arrived on the Tibetan plateau from the northeast approximately 13,000 years ago.  Over time they migrated throughout the region with large numbers settling along the Tsangpo River, which runs parallel to the Himalayas in southern Tibet.

Tibetans are believed to have evolved from the Qiang, one of the first ethnic groups to be referred to in Chinese historical records.  They were mentioned in the 12th century B.C. by members of the Chinese Zhou dynasty, who originated from the western plains near the mountains of Gansu where the Qiang lived.  The Zhou identified the Qiang as allies and the two groups were very similar and may have exchanged women.

In the 6th century B.C. as the Zhou and Chinese become increasingly involved in intensive agriculture the Qiang began migrating towards their present homeland in Sichuan.  There were reports of Qiang states into Read the rest of this entry

IHS PRESENTS NEW MORGELLONS DOCUMENTARY – “Folie à Deux and Other Tales Of Morgellons and Nano”

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‘Folie à deux and other tales of Morgellons and Nano’ is a no-budget documentary film derived from a series of interviews conducted between 2008-2010, on the subject of Morgellons Disease. This film will be making history by offering images and information that has never been available to the general public, until now. First time producer/director Veronica Hendricks offers the world the opportunity to open a new, desperately needed dialog on a subject that is as complex as it is controversial. ‘Folie à deux and other tales of Morgellons and Nano’, focuses on the human aspect of this important issue and gives sufferers of Morgellons disease an explanation to a problem most doctors believe exists only in the mind. Written by Anonymous

The Film features the scientific research of :

Dr. Hildegarde Staninger®, RIET-1

 For Signed Director’s Copy CALL:   

323-466-2599  ~  $ 19.99  ~

Every purchase of the film will allow you to receive
50% off a 30-minute $100 Consultation = only $50
with Dr. Hildegarde Staninger®, RIET-1
~Talk about the movie and YOU ~

~ Integrative Health Systems®, LLC ~
415 ¾ N. Larchmont Blvd.
Los Angeles, CA 90004
323-466-2599

ihs-institute@sbcglobal.net ~ www.onecellonelightradio.wordpress.com
http://www.integrativehs.com

Folie à Deux and other tales of Morgellons and Nano – Website http://www.folieadeuxandothertalesofmorgellonsandnano.com

Folie à Deux and other tales of Morgellons and Nano – Trailer http://www.folieadeuxandothertalesofmorgellonsandnano.com/#!video-foliea-deux-trailers/cguv

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Veronica’s Story:

I’ve been researching Morgellons since spring of 2008, when I witnessed the most frightening thing I’ve ever seen, a nano wire moving in and out of my friend’s chest.

Read the rest of this entry

GET THOSE SKEETERS! HOME-MADE MOSQUITO TRAP

DON’T BUG ME SPECIAL from Dr. Hildy

  HOME-MADE MOSQUITO TRAP INSTRUCTIONS

HOME-MADE MOSQUITO TRAP INSTRUCTIONS

INSTRUCTIONS FOR MAKING A HOME-MADE

MOSQUITO TRAP

 

Instructions

1.  Cut a plastic bottle in half, keep both parts. Can be soft drink bottle.

2.  Take the lower portion of the bottle. Dissolve the brown sugar in hot water. Let it cool down to ~70 deg F (room temperature).

3.  Add the yeast. Carbon dioxide will be formed and will attract the mosquitoes.

4.  Cover the bottle with a dark wrap and insert in the top portion upside down like a funnel. Place it in a corner in your house.

5. In 2 weeks you will be surprised by the number of mosquitoes killed. Read the rest of this entry