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Believe Me: My Battle with the Invisible Disability of Lyme Disease by Yolanda Hadid

YOLANDA HADID’s NEW BOOK

Believe Me: My Battle with the Invisible
Disability of Lyme Disease
by Yolanda Hadid
St. Martin’s Press © 2017

To ALL Our Fans at “One Cell One Light®” Radio Show:

I want to guide you to read the book by Ms. Yolanda Hadid, entitled Believe Me: My Battle with the Invisible Disability of Lyme Disease, which just hit the book shelves on September 12, 2017. (www.amazon.com & www.barnesandnoble.com)

The book brings out the various healthcare providers she saw throughout her journey to recovery in her battle against Lyme Disease. She even discusses on certain pages going to see her toxicologist, Dr. Hildegarde Staninger®, RIET-1, where she learned about essential oils, rose and orange water.

Over the years I have recommended to Lyme and other patients/clients the essential oil soft gels such as Slim & Sassy; Triease; Digest Zen and On Guard, manufactured by doTerra® (www.doterra.con/drhildy).  And  don’t  forget  my recipes for Orange and Rose water we use in our Dr. Hildy®’s Whole Body Detoxification and Environmental Health Educational Programs (.pdf).   They are quite refreshing.

Currently, I have reviewed the ingredients of a coffee that is designed to stimulate internal thermogenesis, which interact with your mitochondria and stimulates heat production, so it will allow the mitochondria to function properly as it burns fat (to reduce weight) and increase circulation. It is called Revital U Brew. It is known to reset your cells to remember who they were originally as created. This is so important to so many environmental stress factor exposures that may lead to increasing the potential risk of initiating an illness or disease over time. www.revitalu.com/drhildy

Revital U Brew was introduced to my listeners on the One Cell One Light Radio Show during our Labor Day Weekend Show, September 4, 2017. “Flowers are for Beauty, Fruit and Nuts are for Health,”  (https://onecellonelightradio.wordpress.com/2017/09/04/dr-hildy-presents-flowers/ ) because a coffee bean is a hard nut to crack and that is why we grind it.

Coming soon, before the year 2017 is over, we will have a show about my new book Cricket the K-Town Kitty: A Tale of Who I Am . Our special guest on the show will  be the leading authoritarian on Ancient Cat Ancestry, as reported in the National Geographic magazine, Dr. Leslie Lyons, Professor, University of Missouri.

Purchase these new books so you will know the answers to the special prize questions, when you try to win a very SPECIAL Dr. HILDY PRIZE that includes the new Baci Mi®  Gel “Ciao Ciao Meow” in honor Cricket the K-Town Kitty.  (An announcement for ordering will be published here when the book is released – soon! –  by the publisher – Cricket the K-Town Kitty: A Tale of Who I Am )

Ciao Ciao Meow from
Dr. Hildy
®  and Cricket the K-Town Kitty
© September 18, 2017

Integrative Health Systems®, LLC
415 ¾ N. Larchmont Blvd.
Los Angeles, CA 90004
Phone: 323-466-2599
Fax: 323-466-2774

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FROM THE DESK OF DR. HILDY® – Acetaminophen and Paracetamol – Glutathione Reaction

COME visit the website and listen to the July 10, 2013
OneCellOneLightRadio show with Dr. Hildy® – 1-3:00PM Pacific
 and archived thereafter – 
TODAY’S SUBJECT:
*GLUTATHIONE and It’s Role In The Biotransformation of TOXICANTS*
.
Life and Health Enhancing information!
.
FROM THE DESK OF DR. HILDY®
by Dr. Hildegarde Staninger®, RIET-1
© July 1, 2013

ACETAMINOPHEN & PARACETAMOL and THEIR REACTION TO GLUTATHIONE

Recently, I co-authored a paper that is being published by the National Registry of Environmental ProfessionalsTM, Glenview, IL for their Professional Journal.   The paper is entitled:  “Glutathione and Its Role in the Biotransformation of Toxicants.”  The paper is a must read paper for anyone who has been exposed to industrial solvents, venoms, hazardous materials, medications and other toxic chemical substances.    The paper did not address a primary study that was conducted by J.R. Mitchell (1973) which specifically addressed the protective role of glutathione upon induced hepatic necrosis from exposure to the compound acetaminophen (paracetamol, the international nonproprietary name) an active ingredient in the medication Tylenol®.1, 2, 3a,b

The paper discusses the role of Xenobiotics and their metabolites.   A xenobiotic is a chemical which is found in an organism but which is not normally produced or expected to be present in it. It can also cover substances which are present in much higher concentrations than are usual. Specifically, drugs such as antibiotics are xenobiotics in humans because the human body does not produce them itself, nor are they part of a normal diet.

Natural compounds can also become xenobiotics if they are taken up by another organism, such as the uptake of natural human hormones by fish found downstream of sewage treatment plant outfalls, or the chemical defenses produced by some organisms as protection against predators.

However, the term xenobiotics is very often used in the context of pollutants such as dioxins and polychlorinated biphenyls and their effect on the biota, because xenobiotics are understood as substances foreign to an entire biological system, i.e. artificial substances, which did not exist in nature before their synthesis by humans. The term xenobiotic is derived from the Greek words ξένος (xenos) = foreigner, stranger and βίος (bios, vios) = life, plus the Greek suffix for adjectives -τικός, -ή, -ό (tic).4 a, b

Free reactive electrophilic intermediates of xenobiotics can produce damage to important cellular consitituents.  Reduced gluathione and the glutathione S-transferase protect cells from this damage by capturing reactive electrophiles before they react at nuceleophilic sites critical to cell viability.5

The metabolism of acetaminophen, an analgesic that at high doses can produced hepatic necrosis, serves as an example of this protective system.  A large body of work has shown that one of the principal ways in which acetaminophen produces its hepatotoxicity is via the reactive intermediate, N-acetyl-p-benzoquinone imines shown in Figure 1.  This intermediate is apparently a soft electrophile that reacts readily with the strong, soft nucleophile glutathione.  As long as the amount of glutathione present at the site of activation of acetaminophen is sufficient to bind the reactive intermediate, no toxicity ensues.  However, as was demonstrated in a classic study by Mitchell et al.6, when glutathone is depleted by pretreatment with diethylmaleate, the benzoquinone imine covalently binds to tissue proteins resulting in tissue necrosis.  Mitchell et. al.6 were among the first to propose that glutathione plays a fundamental role in protecting tissue against electrophilic attack by xenobiotics.7

Since these early studies demonstrating the protective role of glutathione, many compounds have been shown to form conjugates with glutathione.  The protective interaction of glutathione and its primary sulfur dependent enzyme, glutathione-S-transferase play a major role in hormonal regulation of substrate supply to the small intestine.  Insulin, glycogen, and catecholamines are the most important hormones that regulate the supply of glucose, fatty acids, and ketone bodies in most tissue.  Early studies by W.C. Hulsmann concluded that the direct effect of these hormones on small intestinal epithelium may be modest or negligible, while interaction of streptozotocin-diabetic rat, showed the vascularly profused small intestine diminished glucose utilization.  This, however, is probably due to the glucose sparing action of fatty acids and ketone bodies upon intestinal energy metabolism, because of the observation that in diabetes the rate of lactate formation is not decreased.8 a,b, 9

It is very important to note that glutathione plays a major role in detoxification, walling up the toxicants and adding a chain of beneficial mechanisms need to protect one from the chronic effects of hormones, such as thyroid hormones and glucocorticoids that are further stimulated or inhibited upon exposure to thiols/mercaptans.10

REFERENCES

1)  Staninger, Hildegarde and Daniel F. Farrier.  Glutathione and Its Role in the Biotransformation of Toxicants.  Journal of the National Registry of Environmental Professionals.  Glenview, IL  © June 28, 2013.

2)  Sacarello, Hildegarde and Scott J. Evans.  Genetic Cancer Risk Assessment of Electrophilic Hydrocarbon Mixtures in Subsurface Water Supplies. US EPA Agency:  Research and Development.  Symposium on short-Term Genetic Bioassays in the Evaluation of Complex Environmental Mixtures.  Hotel Europa.  Chapel Hill, North Carolina.  March 27-29, 1984

3) (a) Hayes, A. Wallace.  Principles and Methods of Toxicology, Second Edition. Chapter 2:  Metabolism: A Determinant of Toxicity by J. Donald deBethizy and Johnnie R. Hayes.  Raven Press, Ltd., New York, New York © 1989 pgs 29-69.

(b) http://en.wikipedia.org/wiki/Tylenol

4)  (a) http://en.wikipedia.org/wiki/Xenobiotic.com

(b) Mentuccia, Roberto and Hildegarde Staninger.  Increase or Boost Your Metabolism.   Integrative Health Systems®, LLC.  Los Angeles, CA  © June 7, 2011

5)  Mitchell, J.R. Acetaminophen-induced hepatic necrosis.  IV. Protective role of glutathione.  J. Pharmacol. Exp. Ther., 187: 211-217, © 1973

6)  Mohandas, J., Duggin, G.G., Horvath, J.S. and D.J. Tiller.  Metabolic oxidation of acetaminophen (paracetamol) mediated by cytochorme P-450 mixed-function oxidase and prostaglandin endoperoxide synthetase in rabbit kidney.  Toxicol. Appl. Pharmacol.  61:252-259.

7)  Morgan, E.T., and M.J. Coon.  Effects of cytochrome b5 on cytochrome P-450 catalyzed reactions:  Studies withmanganese substituted cytochrome b5. Drug Metab. Dispos., 12: 358-364.

8) (a) Hulsmann, W.C.  Abnormal stress reactions after feeding diets rich in (very) long chain fatty acids:  high levels of corticosterone and testosterone.  Mol. Cell. Endocrinol., 12: 1-8 (C) 1978

(b)  Hulsmann, W.C.  Energy metabolism in different preparations of rat small intestinal epithelium.  In:  Intestinal Permeation.  Proceedings of the Fourth Workshop Conference Hoescht, edited by M. Kramer and F. Lauterbach, pp. 229-239.  Excerpta Medica Intern. Congress Series 391, Excerpta Medica, Amsterdam.

9.  Lamers, J.M.J. and W.C. Hulsmann. The effects of fructose on the stores of energy-rich phosphate in rat jejunum in vivo.   Biochim.  Biophys. Acta.  313: 1-8. © 1973

10.  Schille, Carol M.  Intestinal Toxicology.  Target Organ Toxicology Series.  Editor-in-Chief Robert L. Dixon.  Raven Press, Ltd.  New York, New York © 1984

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4/3/12 – FromTheDeskOfDrHildy: Series 3 – Poison’s My Game! What’s Yours? Nano Crystals and Modified Food Starches

From the Desk of Dr. Hildy™

© April 2, 2012

Series 3: Poison’s My Game! What’s Yours?     

Poison's My Game! What's Yours?

Poison’s My Game! What’s Yours?

Nano Crystals and Modified Food Starches 

I have been asked by several of my associates to condense this particular blog into terms that the average reader may relate to in their home, work environment or within their everyday life style.   Well, if anyone knows me, sometimes it is hard to candy coat a technical piece, make it easier to understand or try to explain something technical to a non-technical minded person – so here goes.

Modified food starch is a term used in industry for any food starch that has something added to it or changed from its original form.  Food starches come from potatoes, corn and other similar produce that has a high starch yield in its chemical composition.   You may use corn starch to thicken your gravies, make fruit pie filling Read the rest of this entry

4/2/12-FROM THE DESK OF DR. HILDY-Series 2- BioEthnoticity and Nanotechnology – Cinnabar and Nanocheops

From the Desk of Dr. Hildy™

© March 6, 2012

Series 2: BioEthnoticity & Nanotechnology 

CINNABAR and NANOCHEOPS

Emperor Qin Shibuangdi, First Emperor of the Ming-dynasty

Emperor Qin Shibuangdi, First Emperor of the Ming-dynasty

Cinnabar was “truly one” with Qin Shibuangdi, First Emperor of the Ming-dynasty (ruled 221-210 BCE) and the earliest known imperial patron of alchemy, next to Rudolf the Great of Hapsburg in 1218 AD for Europe.  Despite the time periods Confucian disapproval of both the First Emperor and his fondness of alchemy, the ingestion of gold – or, rather, the transformed gold- appears to have remained quite popular throughout the Han dynasty.   However, most Han dynasty alchemists worked with cinnabar, sometimes with fatal results.  Cinnabar (mercury sulfide) is an ore of mercury that is a deep vermilion in color.  When heated, cinnabar produces liquid mercury, and further heating and combination of mercury and sulfur will in turn reproduce cinnabar (a cyclical transformation that particularly intrigued Chinese alchemists).  Mercury was further amalgamated with other metals (gold and lead in particular) producing elixirs to be ingested. While cinnabar itself was non-toxic- indeed it still maintains a prominent place in traditional Chinese medicine –

Read the rest of this entry

3/7/2012 – FROM THE DESK OF DR. HILDY

~ Dr. Einstein Speaks ~

~ Dr. Einstein Speaks ~

 
Mount Hildegardicus

From the Desk of Dr. Hildy®

                                                                             Series 1

March 6, 2012                                VITAMINS and MINERALS

I want to thank all of the readers of this blog/column for joining us here, for you will gain tidbits of information to help yourselves in your everyday life and reduce your exposure to toxic substances from our environment and other areas where exposures occur.   Over the last 4 decades of gaining knowledge about vitamins and minerals, I have learned the important roles they serve in our physiology and cellular metabolic applications.  Since the introduction of hazardous materials, toxic substances, exposures to mold, advanced nano materials and many other parameters that synergistically effect life’s cellular activities, all life has been affected to a maximum degree by their toxicological effects.  These effects are many times subtle, due to the human body always trying to make up for something going on within its basic cell structure, tissues and organ systems.

I will be writing this blog/column to bring to my readers information I feel is important to know, learn and to utilize in your everyday life, because everyone must take care of themselves, then they can take care of others – especially their family members.

Read the rest of this entry