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FromTheDeskOf Dr. Hildy: NANO BUILDING BLOCKS: Polymers, Wires and Composites

FROM THE DESK OF DR. Hildy®
© May 12, 2015

NANO BUILDING BLOCKS:  Polymers, Wires and Composites 
“A Collection of Updates in the Big World of Nanotechnology”

In the BIG World of Nanotechnology many individual compounds are used that are known to be hazardous materials and/or toxic substances are now being applied to the innovative and creative architectural design of bio-scaffolding, nano coatings, thin films and 3-D Bio-Printing and regular 3-D printing processes to name a few aspects of their use.

In the May 2015 issue of the Smithsonian, the magazine clearly sates the “Future is Here” as it specifically addresses topics of communicating brain to brain; farm to table organic suburbs; made to order bones and organs and fighting famine and drought with satellites.   In each of these processes a form of a nano advanced materials is used as a composite composed of a base polymer (of a known plastic raw materials).  It may be used to make a human ear and/or develop a brain cloud network of MEMS or nano-siliconCMOS neural dust sensors, so you may transfer your thoughts to another cloud brained archived brain or into your own after selecting the memory or function you desire.

In any event the use of polymers, wires and their composite materials are the nano building blocks to make a nano tool, which becomes the micro device.   The single building blocks as a nanotechnology term or nano advanced material that is composed of toxic individual compounds that are even maded from polymeric plastics such as Styrofoam®, phthalates, vinyl chloride, butadiene rubber and many more that are known human carcinogens are now being used in the following aspects of beauty, cosmetics, medicine and pharmaceutical industries as nano delivery systems are illustrated in their particular use and/or smart function aspect.

A primary concern to human and wildlife is the use of these same materials for a SCADA system(s) as integrated through visWi-Fi, Satellite, Wi-Fi, Radio Frequency and many other forms of energy field transmissions, which have been designed for remote human monitoring, internal biological monitoring and environmental monitoring areas are  all real. Billions of dollars are spent each year in military and medical research to refined their capabilities in these areas as documented in the National Nanotechnology Initiative Supplement to the President’s 2015 Budget, National Science and Technology Council, Subcommittee on Nanoscale Science, Engineering and Technology, March 2014, Washington, DC.  This is only the beginning of waking up to the Big Nano World and how it will impact your life for either the good or the bad.  So Rip van Winkle it is time to wake up and smell the roses before a nanobot gets you with the venom of a polymer resin. Read the rest of this entry

FROM THE DESK OF DR. HILDY® – Acetaminophen and Paracetamol – Glutathione Reaction

COME visit the website and listen to the July 10, 2013
OneCellOneLightRadio show with Dr. Hildy® – 1-3:00PM Pacific
 and archived thereafter – 
TODAY’S SUBJECT:
*GLUTATHIONE and It’s Role In The Biotransformation of TOXICANTS*
.
Life and Health Enhancing information!
.
FROM THE DESK OF DR. HILDY®
by Dr. Hildegarde Staninger®, RIET-1
© July 1, 2013

ACETAMINOPHEN & PARACETAMOL and THEIR REACTION TO GLUTATHIONE

Recently, I co-authored a paper that is being published by the National Registry of Environmental ProfessionalsTM, Glenview, IL for their Professional Journal.   The paper is entitled:  “Glutathione and Its Role in the Biotransformation of Toxicants.”  The paper is a must read paper for anyone who has been exposed to industrial solvents, venoms, hazardous materials, medications and other toxic chemical substances.    The paper did not address a primary study that was conducted by J.R. Mitchell (1973) which specifically addressed the protective role of glutathione upon induced hepatic necrosis from exposure to the compound acetaminophen (paracetamol, the international nonproprietary name) an active ingredient in the medication Tylenol®.1, 2, 3a,b

The paper discusses the role of Xenobiotics and their metabolites.   A xenobiotic is a chemical which is found in an organism but which is not normally produced or expected to be present in it. It can also cover substances which are present in much higher concentrations than are usual. Specifically, drugs such as antibiotics are xenobiotics in humans because the human body does not produce them itself, nor are they part of a normal diet.

Natural compounds can also become xenobiotics if they are taken up by another organism, such as the uptake of natural human hormones by fish found downstream of sewage treatment plant outfalls, or the chemical defenses produced by some organisms as protection against predators.

However, the term xenobiotics is very often used in the context of pollutants such as dioxins and polychlorinated biphenyls and their effect on the biota, because xenobiotics are understood as substances foreign to an entire biological system, i.e. artificial substances, which did not exist in nature before their synthesis by humans. The term xenobiotic is derived from the Greek words ξένος (xenos) = foreigner, stranger and βίος (bios, vios) = life, plus the Greek suffix for adjectives -τικός, -ή, -ό (tic).4 a, b

Free reactive electrophilic intermediates of xenobiotics can produce damage to important cellular consitituents.  Reduced gluathione and the glutathione S-transferase protect cells from this damage by capturing reactive electrophiles before they react at nuceleophilic sites critical to cell viability.5

The metabolism of acetaminophen, an analgesic that at high doses can produced hepatic necrosis, serves as an example of this protective system.  A large body of work has shown that one of the principal ways in which acetaminophen produces its hepatotoxicity is via the reactive intermediate, N-acetyl-p-benzoquinone imines shown in Figure 1.  This intermediate is apparently a soft electrophile that reacts readily with the strong, soft nucleophile glutathione.  As long as the amount of glutathione present at the site of activation of acetaminophen is sufficient to bind the reactive intermediate, no toxicity ensues.  However, as was demonstrated in a classic study by Mitchell et al.6, when glutathone is depleted by pretreatment with diethylmaleate, the benzoquinone imine covalently binds to tissue proteins resulting in tissue necrosis.  Mitchell et. al.6 were among the first to propose that glutathione plays a fundamental role in protecting tissue against electrophilic attack by xenobiotics.7

Since these early studies demonstrating the protective role of glutathione, many compounds have been shown to form conjugates with glutathione.  The protective interaction of glutathione and its primary sulfur dependent enzyme, glutathione-S-transferase play a major role in hormonal regulation of substrate supply to the small intestine.  Insulin, glycogen, and catecholamines are the most important hormones that regulate the supply of glucose, fatty acids, and ketone bodies in most tissue.  Early studies by W.C. Hulsmann concluded that the direct effect of these hormones on small intestinal epithelium may be modest or negligible, while interaction of streptozotocin-diabetic rat, showed the vascularly profused small intestine diminished glucose utilization.  This, however, is probably due to the glucose sparing action of fatty acids and ketone bodies upon intestinal energy metabolism, because of the observation that in diabetes the rate of lactate formation is not decreased.8 a,b, 9

It is very important to note that glutathione plays a major role in detoxification, walling up the toxicants and adding a chain of beneficial mechanisms need to protect one from the chronic effects of hormones, such as thyroid hormones and glucocorticoids that are further stimulated or inhibited upon exposure to thiols/mercaptans.10

REFERENCES

1)  Staninger, Hildegarde and Daniel F. Farrier.  Glutathione and Its Role in the Biotransformation of Toxicants.  Journal of the National Registry of Environmental Professionals.  Glenview, IL  © June 28, 2013.

2)  Sacarello, Hildegarde and Scott J. Evans.  Genetic Cancer Risk Assessment of Electrophilic Hydrocarbon Mixtures in Subsurface Water Supplies. US EPA Agency:  Research and Development.  Symposium on short-Term Genetic Bioassays in the Evaluation of Complex Environmental Mixtures.  Hotel Europa.  Chapel Hill, North Carolina.  March 27-29, 1984

3) (a) Hayes, A. Wallace.  Principles and Methods of Toxicology, Second Edition. Chapter 2:  Metabolism: A Determinant of Toxicity by J. Donald deBethizy and Johnnie R. Hayes.  Raven Press, Ltd., New York, New York © 1989 pgs 29-69.

(b) http://en.wikipedia.org/wiki/Tylenol

4)  (a) http://en.wikipedia.org/wiki/Xenobiotic.com

(b) Mentuccia, Roberto and Hildegarde Staninger.  Increase or Boost Your Metabolism.   Integrative Health Systems®, LLC.  Los Angeles, CA  © June 7, 2011

5)  Mitchell, J.R. Acetaminophen-induced hepatic necrosis.  IV. Protective role of glutathione.  J. Pharmacol. Exp. Ther., 187: 211-217, © 1973

6)  Mohandas, J., Duggin, G.G., Horvath, J.S. and D.J. Tiller.  Metabolic oxidation of acetaminophen (paracetamol) mediated by cytochorme P-450 mixed-function oxidase and prostaglandin endoperoxide synthetase in rabbit kidney.  Toxicol. Appl. Pharmacol.  61:252-259.

7)  Morgan, E.T., and M.J. Coon.  Effects of cytochrome b5 on cytochrome P-450 catalyzed reactions:  Studies withmanganese substituted cytochrome b5. Drug Metab. Dispos., 12: 358-364.

8) (a) Hulsmann, W.C.  Abnormal stress reactions after feeding diets rich in (very) long chain fatty acids:  high levels of corticosterone and testosterone.  Mol. Cell. Endocrinol., 12: 1-8 (C) 1978

(b)  Hulsmann, W.C.  Energy metabolism in different preparations of rat small intestinal epithelium.  In:  Intestinal Permeation.  Proceedings of the Fourth Workshop Conference Hoescht, edited by M. Kramer and F. Lauterbach, pp. 229-239.  Excerpta Medica Intern. Congress Series 391, Excerpta Medica, Amsterdam.

9.  Lamers, J.M.J. and W.C. Hulsmann. The effects of fructose on the stores of energy-rich phosphate in rat jejunum in vivo.   Biochim.  Biophys. Acta.  313: 1-8. © 1973

10.  Schille, Carol M.  Intestinal Toxicology.  Target Organ Toxicology Series.  Editor-in-Chief Robert L. Dixon.  Raven Press, Ltd.  New York, New York © 1984

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9/21/12 – FROM THE DESK of DR. HILDY – WATERMELON !!

From the Desk of Dr. Hildy    ~~WATERMELON !!~~

H. Staninger© Sept. 4, 2012

IHS BioEthno Medicinal Botanicals Of Antiquity
 **Old World Medicinal Plants**

Available from:
Integrative Health Systems, LLC – 323-466-2599
http://www.1cellonelight.com/pdf/Plantain-Bitter-Melon-and-Acai[1].pdf

Did you know that the watermelon is really a berry?  And what a sweet and delicious fruit it is to all of us who have eaten it during these long hot “microwavable” summers that stretch around the world.  Whether it is a little sugar baby or just a long green one it is always refreshing on hot summer day.   The fruit, rind and even the seeds have been known for their therapeutic medicinal use in ancient times in Persia, Egypt, Spain, Rome and Greece.

Watermelon has been reported as a very helpful in correcting abnormal kidney conditions, such as polycystic kidney, exposure to mycotoxins (Balkan Disease) and aids in the reduction of adenovirus within the kidney tissue.  Apparently there is an ingredient in the seeds, Cucurbocitrin, which has the effect of dilating the capillaries, the tiny blood vessels of the body.  Consequently, the pressure upon the large blood vessels within the kidney are then reduced.

 

Watermelon wedges are popular as desserts and they are also used in fruit salads, smoothies, popsicles, or mixed in a salad with pieces of cantaloupes, pears, apples and other fruits and berries.  It is quite a treat on a very HOT day, especially when served Ice cold.

Read the rest of this entry

FROM THE DESK OF DR. HILDY™ – Botanicals of Antiquity – BAY LEAVES

FROM THE DESK OF DR. HILDY™                    

by Dr. Hildegarde Staninger, RIET-1    

Series 4:  Botanicals of Antiquity        BAY LEAVES

© August 3, 2012

Bay leaves have been used in culinary dishes from all over the word to give the tasty dish a “little zing” since ancient times. The bay tree belongs to the family of Laurraceane of the genus Laurus nobilis.   It is thought to originate from Asia Minor, but spread all over the Mediterranean and Asia during earlier times. 

Bay Leaf Tree

The bay plant is a conical evergreen tree growing to 30 feet in height.  Yellow or greenish white, star shaped flowers appear during early spring, which subsequently produce dark green-purplish single seeded berry.  The leaves are eliptic and shiny dark green about 3 to 4 inches long, rather thick and leathery.  

The leaves give off a sweet aroma when broken and added to a dish or your flour container to keep it fresh.  When slightly wilted and dried, they are strongly aromatic.  The dried fruit is also used as a flavoring agent in cuisines.

If you want to use it as a lymphatic and central nervous system detoxifying water, cell

BAY LEAF

BAY LEAF

regenerator as it nurtures your body back to health I personally recommend the following Dr. Hildy™ recipe.   Add 8 bay leaves to 4 quarts of water (spaghetti pot size to hold the water).    Bring to a boil, and then set to a side, off the burner.  Let steep 15 minutes or longer.   Pour into a pitcher as it cools down and keep in the refrigerator.  Serve as a refreshing drink. After drinking two glasses (approximately 10- to 12 ounces each) you may experience its detoxifying effects as it cleans out the nervous system of the lymph glands and CNS.  You will feel it strip the toxic build up away.  In cases where an individual may have been exposed to aromatic solvents, organophosphates/carbamates and silanes/siloxanes the bay leaf water will clean out the spinal cord and 350 glands within the individuals head.  You may experience a sweating from the crown of your head to the tip of your spine.  Quite refreshing and invigorating as the more you clean this target organ system.

The health benefits of bay leaf are the following: 

  • ·        Bay leaf was highly praised by the Greeks and the Romans, who thought that the herb was symbolic of wisdom, peace and protection.
  • ·        The spice contains many notable plant derived compounds, minerals and vitamins that are essential for optimum health, detox and cellular regeneration.
  • ·        This spice has many volatile active components such as alpha-pinene, beta-pinene, myrcene, limonene, linalool, methyl chavicol, neral, alpha terpineol, Read the rest of this entry

FROM THE DESK OF DR. HILDY™ – Series 4: Healing Botanicals From Antiquity – Baci Mi™ Oxygenated Coconut Oil

FROM THE DESK OF DR. HILDY™          © July 17, 2012

               Series 4: Healing Botanicals From Antiquity

                                BACI MI™ OXYGENATED COCONUT OIL
                                         A Natural Elixir from the Tropics

 by Dr. Hildegarde Staninger™, RIET-1 

The Tree Of Life

The Tree Of Life

The coconut, which is loaded with fiber, vitamins and minerals, is rich with nutrition and is classified as a functional food.  Its luxurious and fragrant oil is highly prized for its healing properties which go far beyond any other dietary oil.  Pacific Islanders consider it to be the cure for all illness. 

Coconut

Coconut

The coconut palm is so highly revered as a source of food and medicine by Pacific Islanders that it is called “The Tree of Life.”  This curative oil is full of health benefits.  It’s a natural anti-aging elixir to beauty, skin and hair and boosts the immune system.  It’s also a healing salve for inflammation, wounds or pain anywhere on the body.  It eradicates scars, keloids, psoriasis, acne, cracked and flaking skin.  After bathing, it automatically restores skin’s proper pH.  It controls dandruff and head lice and soothes diaper rash.

Skin

Skin

Along with reducing inflammation, coconut oil supports tissue healing and repair.  When  applied topically, it helps form a chemical barrier on the skin to ward off infection.  Use it as a moisturizer, night cream, or serum on your face and watch the scars, wrinkles and tiny lines magically disappear as it restores the skin’s texture, elasticity and clarity.

Baci Mi Oxygenated Coconut OIl

Baci Mi Oxygenated Coconut OIl

The inclusion of oxygen and ozone in this wondrous synergistic blend rejuvenates the body and leads to the repair of every cell.  This is important, because as we age our oxygen supply is depleted and often leaves us vulnerable to attack from pathogens.  Coconut oil becomes liquid at 76 degrees.  Still, it continues to be effective either in solid or liquid form.  Refrigerate it if you want to keep it solid in warm weather.

There are at least 25 other things that Coconut Oil has been known to help your body as it is detoxified, rejuvenates and nurtures itself in Read the rest of this entry

6/27/12 – FROM THE DESK OF DR. HILDY™ – Vitamin B-12

FROM THE DESK OF DR. HILDY™                  VITAMIN B12

by Dr. Hildegarde Staninger, RIET-1         Series 1:  Vitamins & Minerals

© May 26, 2012

Vitamin B-12 Sources

(This vitamin is found mainly in liver, kidney, muscle meats, oysters, milk, eggs, cheese and salt-water fish.  Of the vegetable foods, yeast, wheat germ and soybeans have cobalimin content, but  only small traces of it.)

ONE CELL ONE LIGHT RADIO
with Dr. Hildegarde Staninger

LISTEN TO HOUR 2 – Dr. Hildy and Shoshanna discuss B-VITAMINS and specifically Vitamin B-6 and then Vitamin B-12

~~~ Archived here for your listening convenience~~~
http://www.blogtalkradio.com/onecellonelightradio/2012/06/27/62712-drhildy-sandra-lemiree-girls-entrepreneurial-women

This vitamin is essential for the blood-forming organs of the bone marrow if they are to function properly.  Also, the nervous system depends upon this vitamin for nutrition.  One of the ingredients of this vitamin is cobalt, and it appears from the study of scientific materials that Vitamin B12 is now being referred to as cobalamin, because of the importance of cobalt in the diet.  Likewise, zinc is associated with this vitamin, the studies indicating that the vitamin cannot be synthesized without the help of zinc.  Vitamin B12 is also needed to help form hemoglobin scale.  Thus this vitamin is important for the prevention of anemia.  It also combines with folic acid to help produce the vital red blood cells.  Actually, it has been stated that less than one millionth of a gram of cobalamin is needed daily to meet the human body requirements.

The lack of cobalamin may cause pernicious anemia, due to the inability of the bone marrow to form blood when this vitamin is absent.  A symptom of lack of cobalamin is a shuffling gait.  Another indication is a loss of sense of position of the feet.  In severe cases, where there has been a degeneration of the spinal cord, there may be nerve and brain damage and even complete paralysis.

Another result of this deficiency is general malnutrition, marked by an insufficient production of sex hormones with the resultant lack of development or shriveling of Read the rest of this entry

4/6/12 – FROM THE DESK OF DR. HILDY: Celebrate Treasured Polish Custom of “Pisanki’ Coloring, Displaying of Easter Eggs

From the Desk of Dr. Hildy                       

© April 6, 2012                               Series 2: BioEthnic & Nanotechnology

Celebrate the Treasured Polish Custom of “Pisanki”  Coloring and Displaying of Easter Eggs

Pisanki

Pisanki

I want to wish all of my readers and viewers a blessed Easter, Passover and a Happy Spring Time.   Los Angeles, California is home to a variety of Ethnic communities, but due to the celebration of Easter and the coloring of the “Easter Egg.”  I feel it is important for my readers and viewers  to know the Polish tradition of “Pisanki” the coloring of eggs.

The pisanki traditions are derived from an ancient tradition when eggs, the symbol of life,

Pisanki

Pisanki

were endowed with magical properties and were thought to ensure both a plentiful harvest and good health.  The name Pisanki comes from the Polish word “pisac’”, which means to write. The practice of coloring Easter eggs is very much alive in Poland today, just as it is tradition in all households of the world who celebrate the arrival of Peter Cotton Tail and his fellow companions.   Polish people have enjoyed this tradition, Read the rest of this entry

4/3/12 – FromTheDeskOfDrHildy: Series 3 – Poison’s My Game! What’s Yours? Nano Crystals and Modified Food Starches

From the Desk of Dr. Hildy™

© April 2, 2012

Series 3: Poison’s My Game! What’s Yours?     

Poison's My Game! What's Yours?

Poison’s My Game! What’s Yours?

Nano Crystals and Modified Food Starches 

I have been asked by several of my associates to condense this particular blog into terms that the average reader may relate to in their home, work environment or within their everyday life style.   Well, if anyone knows me, sometimes it is hard to candy coat a technical piece, make it easier to understand or try to explain something technical to a non-technical minded person – so here goes.

Modified food starch is a term used in industry for any food starch that has something added to it or changed from its original form.  Food starches come from potatoes, corn and other similar produce that has a high starch yield in its chemical composition.   You may use corn starch to thicken your gravies, make fruit pie filling Read the rest of this entry

4/2/12-FROM THE DESK OF DR. HILDY-Series 2- BioEthnoticity and Nanotechnology – Cinnabar and Nanocheops

From the Desk of Dr. Hildy™

© March 6, 2012

Series 2: BioEthnoticity & Nanotechnology 

CINNABAR and NANOCHEOPS

Emperor Qin Shibuangdi, First Emperor of the Ming-dynasty

Emperor Qin Shibuangdi, First Emperor of the Ming-dynasty

Cinnabar was “truly one” with Qin Shibuangdi, First Emperor of the Ming-dynasty (ruled 221-210 BCE) and the earliest known imperial patron of alchemy, next to Rudolf the Great of Hapsburg in 1218 AD for Europe.  Despite the time periods Confucian disapproval of both the First Emperor and his fondness of alchemy, the ingestion of gold – or, rather, the transformed gold- appears to have remained quite popular throughout the Han dynasty.   However, most Han dynasty alchemists worked with cinnabar, sometimes with fatal results.  Cinnabar (mercury sulfide) is an ore of mercury that is a deep vermilion in color.  When heated, cinnabar produces liquid mercury, and further heating and combination of mercury and sulfur will in turn reproduce cinnabar (a cyclical transformation that particularly intrigued Chinese alchemists).  Mercury was further amalgamated with other metals (gold and lead in particular) producing elixirs to be ingested. While cinnabar itself was non-toxic- indeed it still maintains a prominent place in traditional Chinese medicine –

Read the rest of this entry

3/31/12 – FROM THE DESK OF DR. HILDY™- VITAMIN B-1

From the Desk of Dr. Hildy™

St. Patrick’s Day © March 17, 2012

Series 1: Vitamins & Minerals

Vitamin B-1

Vitamin B1 is also known as thiamin or thiamine.  However there are several vitamins in the B complex, and they are all interdependent and should all be taken at the same time.  A failure to have all of the B complex vitamins may lower the body’s resistance to disease.  Thiamine is especially valuable as an aid in the metabolism of carbohydrates.  Unless carbohydrates can be converted into energy, the individual will lack energy, drive and sparkle.  This vitamin is considered essential for reproductive powers and for proper nerve function. 

Wheat Germ B-1

Wheat Germ B-1

An insufficient supply of thiamine can result in a variety of symptoms related to the functioning of the nervous system, such as irritability, insomnia, loss of appetite and constipation.  At times the arms and legs may feel numb due to the unhealthy nerves.  The lack of sufficient thiamine may cause beri-beri, the disease marked by extreme weakness, loss of appetite and weight, digestive disturbances, painful neuritis, and even paralysis.  The heart action is likely to become abnormal and mental depression is a common symptom.  The individual becomes short of breath with by very little exertion.  An insufficient supply of this vitamin also prevents the formation of hydrochloric acid in the stomach, which is needed for digestion of food.  Thiamin is a part of the enzyme system that breaks down pyruvic and lactic acids, releasing energy.  Read the rest of this entry